Copa Sudamericana – Round of 16 (First Leg)

25 September 2012
Independiente – Liverpool
Referee: Jose Buitrago (COL, photo)
Assistant Referee 1: Humberto Clavijo (COL)
Assistant Referee 2: Alexander Guzman (COL)
Fourth Official: Juan Restrepo (COL)

Deportivo Quito – Tigre
Referee: Adrian Velez (COL)
Assistant Referee 1: Eduardo Diaz (COL)
Assistant Referee 2: Wilson Berrio (COL)
Fourth Official: Luis Sanchez (COL)

26 September 2012
Ligua de Loja – Sao Paulo
Referee: Julio Bascunan (CHI)
Assistant Referee 1: Juan Maturana (CHI)
Assistant Referee 2: Marcelo Barraza (CHI)
Fourth Official: Eduardo Gamboa (CHI)

Barcelona – Gremio
Referee: Georges Buckley (PER)
Assistant Referee 1: Raul Lopez (PER)
Assistant Referee 2: Braulio Cornejo (PER)
Fourth Official: Henry Gambetta (PER)

27 September 2012
Colon – Cerro Porteno
Referee: Sandro Ricci (BRA)
Assistant Referee 1: Roberto Braatz (BRA)
Assistant Referee 2: Marcio Santiago (BRA)
Fourth Official: Pericles Cortez (BRA)

2 October 2012
Universidad de Chile – Emelec
Referee: Marcelo Henrique (BRA)
Assistant Referee 1: Altemir Hausmann (BRA)
Assistant Referee 2: Rodrigo Joia (BRA)
Fourth Official: Ricardo Marques (BRA)

Palmeiras – Millonarios
Referee: Patricio Loustau (ARG)
Assistant Referee 1: Gustavo Rossi (ARG)
Assistant Referee 2: Ivan Nunez (ARG)
Fourth Official: German Delfino (ARG)

3 October 2012
Universidad Catolica – Atletico Goianiense
Referee: Enrique Caceres (PAR)
Assistant Referee 1: Rodney Aquino (PAR)
Assistant Referee 2: Cesar Franco (PAR)
Fourth Official: Ulises Mereles (PAR)